Neuroplasticidade hipocampal em modelos animais da doença de Huntington

revisão integrativa

Autores

  • Pamela Sophya Costa Ribeiro Universidade Federal de Santa Catarina
  • Claudia Daniele Bianco Universidade Federal de Santa Catarina
  • Patricia de Souza Brocardo Universidade Federal de Santa Catarina

Palavras-chave:

Doença de Huntington, Hipocampo, Neurogênese, Neuroplasticidade

Resumo

A doença de Huntington (DH) é uma doença neurodegenerativa genética causada por uma repetição do trinucleotídeo CAG no gene codificador da proteína huntingtina. Entre os sintomas destacam-se déficits motores, depressão e déficits cognitivos. Pesquisas pré-clínicas e clínicas buscam compreender os mecanismos patológicos associados aos fatores genéticos para poder propor estratégias terapêuticas para o controle da DH. O estriado é a região cerebral mais estudada na DH. No entanto, sabe-se que o hipocampo também está envolvido nesta doença. Portanto, este trabalho teve como objetivo fazer uma revisão de literatura sobre pesquisas que estudaram a relação entre a DH e o hipocampo.

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Biografia do Autor

Pamela Sophya Costa Ribeiro, Universidade Federal de Santa Catarina

Graduanda na terceira fase do curso de Psicologia na Universidade Federal de Santa Catarina - UFSC. Atualmente é bolsista de Iniciação Científica no laboratório de Neuroplasticidade - LANEP, UFSC. ORCID: https://orcid.org/0000-0001-6006-483X

Claudia Daniele Bianco, Universidade Federal de Santa Catarina

Graduada em Ciências Biológicas – Licenciatura (2017), Mestrado pelo Programa de Pós-Graduação em Neurociências (2019). Atualmente é aluna de Doutorado no Programa de Pós-Graduação em Bioquímica (2019-2023). Todos pela Universidade Federal de Santa Catarina – UFSC.

Patricia de Souza Brocardo, Universidade Federal de Santa Catarina

Possui graduação em Fisioterapia pela Fundação Universidade Regional de Blumenau (1998), mestrado (2004) e doutorado (2008) em Neurociências pela Universidade Federal de Santa Catarina. Pós-doutorado na Universidade de Victoria no Canadá, onde trabalhou com desordens do desenvolvimento e com doenças neurodegenerativas. Tem experiência na área de Neuropsicofarmacologia, Toxicologia, Morfologia, Histologia e Neuroplasticidade atuando principalmente nos seguintes temas: Neuroplasticidade no neurodesenvolvimento e na neurodegeneração. Em 2014 foi uma das ganhadoras do prêmio Para Mulheres na Ciência, uma parceria da LOréal com a Unesco no Brasil e a Academia Brasileira de Ciências (ABC). Atualmente é professora de Histologia no Departamento de Ciências Morfológicas e orientadora de mestrado e doutorado no programa de Pós-graduação em Neurociências na Universidade Federal de Santa Catarina. ORCID: https://orcid.org/0000-0002-1680-5909

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2021-12-09

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Costa Ribeiro, P. S., Bianco, C. D., & de Souza Brocardo, P. (2021). Neuroplasticidade hipocampal em modelos animais da doença de Huntington: revisão integrativa. Revista Brasileira De Iniciação Científica, 8, e021039. Recuperado de https://periodicoscientificos.itp.ifsp.edu.br/index.php/rbic/article/view/84