Hippocampal neuroplasticity in animal models of Huntington's disease

integrative review

Authors

  • Pamela Sophya Costa Ribeiro Universidade Federal de Santa Catarina
  • Claudia Daniele Bianco Universidade Federal de Santa Catarina
  • Patricia de Souza Brocardo Universidade Federal de Santa Catarina

Keywords:

Huntington disease, Hippocampus, Neurogenesis, Neuroplasticity

Abstract

Huntington's disease (HD) is a genetic neurodegenerative disease caused by a CAG trinucleotide repeats in the gene encoding the huntingtin protein. Symptoms include motor deficits, depression, and cognitive deficits. Pre-clinical and clinical research seeks to understand the pathological mechanisms associated with genetic factors to propose therapeutic strategies for HD control. The striatum is the brain region most studied in HD. However, it is known that the hippocampus is also involved in this disease. Therefore, this study aimed to review the literature on research that studied the relationship between HD and the hippocampus.

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Author Biographies

Pamela Sophya Costa Ribeiro, Universidade Federal de Santa Catarina

Undergraduate student in the third phase of the Psychology course at the Federal University of Santa Catarina - UFSC. She is currently a Scientific Initiation fellow at the Neuroplasticity laboratory - LANEP, UFSC.

Claudia Daniele Bianco, Universidade Federal de Santa Catarina

Undergraduated in Biological Sciences - Licenciatura (2017), Master's Degree by the Post-Graduate Program in Neurosciences (2019). She is currently a PhD student in the Biochemistry Graduate Program (2019-2023). All from the Federal University of Santa Catarina - UFSC.

Patricia de Souza Brocardo, Universidade Federal de Santa Catarina

Undergraduate in Physiotherapy from Fundação Universidade Regional de Blumenau (1998), master's degree (2004) and doctorate (2008) in Neurosciences from Universidade Federal de Santa Catarina. Postdoctoral fellow at the University of Victoria in Canada, where he worked with developmental disorders and neurodegenerative diseases. She has experience in Neuropsychopharmacology, Toxicology, Morphology, Histology, and Neuroplasticity, acting on the following subjects: Neuroplasticity in neurodevelopment and neurodegeneration. In 2014 she was one of the winners of the For Women in Science award, a partnership between LOréal with Unesco in Brazil and the Brazilian Academy of Sciences (ABC). She is currently a histology professor at the Department of Morphological Sciences and a master's and doctoral advisor in the Neuroscience Graduate Program at the Federal University of Santa Catarina.

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Costa Ribeiro, P. S., Bianco, C. D., & de Souza Brocardo, P. (2021). Hippocampal neuroplasticity in animal models of Huntington’s disease: integrative review. Revista Brasileira De Iniciação Científica, 8, e021039. Retrieved from https://periodicoscientificos.itp.ifsp.edu.br/index.php/rbic/article/view/84

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